Endocrine Abstracts

Biopharmaceuticals are complex molecules and can show variation between production batches. Physicochemical tests and biological activity measurements contribute complementary data to the characterisation of these products.As part of a project to correlate physicochemical and bioassay data, under the Department of Trade and Industry’s Measurements for Biotechnology programme, we have developed a simple, robust cellbased bioassay protocol for interfe...

Different hypothesis exist about the mechanism of glycose control after bariatric surgery involving intestinal bypass. The aim of our study was to determine the insulin and C-peptide response after test meal (Fresubin drink a 200 ml; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5 days after gastric by pass surgery. Glycaemia (mmol/l; glucose oxidase), insulin (ECLIA, Roche Diagnostics, pmol/l) and C-peptide (ECLIA, Roche Diagnostics, pmol/l) were det...

Aim: Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are prognostic markers of differentiated thyroid cancers. In our study we evaluated NLR, PLR and C-reactive protein for predicting the occurence of differentiated thyroid cancer. This is the first study that compares NLR and PLR to C-reactive protein indifferantiated thyroid cancer not only papillary cancer but also folliculer cancer.Materials and Method: This study includes 51 pa...

Aims: Genetic variations mediating matrix metalloproteinase-2 (MMP-2) expression may result in individual differences in susceptibility to particular diseases. Our aim was to investigate the possible association of certain MMP-2 gene variants with type 2 diabetes mellitus (T2DM) in a Tunisian population.Subjects and Methods: A case-control study involving 310 normoglycemic control subjects and 791 T2D patients was performed. A total of four MMP-2 SNPs (-...

Background: T2DM is a metabolic disorder characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency with disturbances of carbohydrate, fat, and protein metabolism.T2DM is a risk factor for Alzheimer’s disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain, but it is most likely multi factorial. Chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and...

C Ronald Kahn, Joslin Diabetes Centre, Harvard Medical School, Boston, USA AbstractDr C Ronald Kahn was born in Louisville, KY and received his undergraduate and medical degrees from the University of Louisville. After training in internal medicine at Barnes Hospital, St Louis, MO, he joined the NIH as a Clinical Associate in the Endocrinology Branch. Over the next 11 years, he rose to become the Head of the Secti...

Aim: Egypt is among the world’s top 10 countries in terms of the highest number of people with diabetes. Charcot foot is a serious complication that affect bones, joints, and soft tissues of the foot or ankle. Although the etiology is linked to different inflammatory markers, yet not clear. Recently, an association between two polymorphisms (1181G > C and 245T > G) of the osteoprotegerin (OPG) gene and Charcot was suggested. The aim of this study was to explore p...

Introduction: Various hypothesis exist about the mechanism of changes in glucose control and insulin sensitivity after bariatric surgery.Description of methods/design: The aim of our study was to determine glucose, insulin, C-peptide and GLP-1 levels after test meal (Fresubin drink a 200 ml given at 0 min; 200 kcal, 15% protein, 30% fat and 55% carbohydrate) before (day 0) and 5 days after gastric bypass surgery in a 22 obese patients (age: 36.22±12...

Case history: A 32 female was referred to a tertiary maternity unit due to hypercalcaemia and a diagnosis of primary hyperparathyroidism (PHPT). She had learning difficulties, 2 previous C-sections and was a smoker. She presented 5 years earlier to her local hospital with abdominal and leg pains, nausea, constipation and fatigue. She had undergone 2 parathyroidectomies but remained hypercalcaemic and had been managed medically with Cinacalcet when she conceived an unplanned pr...

A range of hormones which regulate energy metabolism are secreted by adipose tissue, among which adiponectin and leptin are the main adipokines regulating insulin sensitivity.The aim of our study was to estimate and compare levels of adiponectin, leptin, C-peptide and adiponectin-to-leptin ratio (A/L) in obese non-diabetic, Type 1 diabetic (T1D) children and lean non-diabetic controls.BMI and SDS BMI were calculated in 88 children ...